反应详情

A mixture of 1.75 g. of 7-hydroxy-5-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine and 15 ml. of phosphorus oxychloride is refluxed for 2 hours. After evaporation at reduced pressure, ice is added to the residue and the desired compound is extracted with methylene chloride. After washing the organic layer with a saturated saline solution and drying with solid anhydrous sodium sulfate, evaporation gives the desired compound, m.p. 137°-139° C.

1. additionA mixture of 1.75 g
2. customAfter evaporation at reduced pressure, ice
3. additionis added to the residue
4. extractionthe desired compound is extracted with methylene chloride
5. washAfter washing the organic layer with a saturated saline solution
6. dry with materialdrying with solid anhydrous sodium sulfate, evaporation