Pyrazole, 3-amino-4-cyano-5-ethyl- → 2-Ethyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

HRID 225290Notes

Reaction equation

HRID 225290 reaction equation
[NH2:1][C:2]1[C:6]([C:7]#[N:8])=[C:5]([CH2:9][CH3:10])[NH:4][N:3]=1.CN(C)[CH:13]=[CH:14][C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=1)=O>>[CH2:9]([C:5]1[C:6]([C:7]#[N:8])=[C:2]2[N:1]=[CH:13][CH:14]=[C:15]([C:17]3[CH:18]=[C:19]([C:23]([F:24])([F:25])[F:26])[CH:20]=[CH:21][CH:22]=3)[N:3]2[N:4]=1)[CH3:10]

Participants

3

Reactant 2

HCID 114021Pyrazole, 3-amino-4-cyano-5-ethyl-HCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenone

Product 1

HCID 233298372-Ethyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

Procedure

As for Example 1, 3-amino-5-ethylpyrazole-4-carbonitrile is reacted with 3-dimethylamino-3'-(trifluoromethyl)acrylophenone to give the product as crystals, m.p. 144°-146° C.

Sources & evidence

ORD record
ord-6445dbd81c5d4434a10a89c831583498
Source dataset
uspto-grants-1980_11
Patent number
US04236005

Reaction notes

Loading…