3-(Dimethylamino)-1-[2-(trifluoromethyl)phenyl]prop-2-en-1-one → Ethyl 7-(alpha,alpha,alpha-trifluoro-o-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

HRID 225293Notes

Reaction equation

HRID 225293 reaction equation
[NH2:1][C:2]1[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][NH:4][N:3]=1.CN(C)[CH:14]=[CH:15][C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:24]([F:27])([F:26])[F:25])=O>>[F:25][C:24]([F:26])([F:27])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:16]1[N:3]2[N:4]=[CH:5][C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[C:2]2[N:1]=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 542598323-(Dimethylamino)-1-[2-(trifluoromethyl)phenyl]prop-2-en-1-oneHCID 178469928HCID 178469928, compound

Product 1

HCID 23329868Ethyl 7-(alpha,alpha,alpha-trifluoro-o-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

Procedure

As for Example 1, ethyl 3-aminopyrazole-4-carboxylate is reacted with 3-dimethylamino-2'-(trifluoromethyl)acrylophenone to give the product as crystals, m.p. 148°-149° C.

Sources & evidence

ORD record
ord-12557a5efb6f429cb75670b4a2ddc1b9
Source dataset
uspto-grants-1980_11
Patent number
US04236005

Reaction notes

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