Hydrochloric Acid → HCID 11543260, compound

HRID 2252991Notes

Reaction equation

HRID 2252991 reaction equation
C([N:8]1[CH2:13][CH2:12][O:11][C@H:10]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[O:21][CH:22]([F:24])[F:23])[CH2:9]1)(OC(C)(C)C)=O.Cl>>[F:24][CH:22]([F:23])[O:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[CH2:14][C@H:10]1[O:11][CH2:12][CH2:13][NH:8][CH2:9]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67073247N-Boc-(R)-2-(2-difluoromethoxybenzyl)morpholine

Product 1

HCID 11543260HCID 11543260, compound

Procedure

Deprotection of intermediate (a), N-Boc-(R)-2-(2-difluoromethoxybenzyl)morpholine using hydrogen chloride (4M, in methanol), afforded the morpholine example 34 as a colorless oil (37 mg, 65%).

Sources & evidence

ORD record
ord-5dd8e4544a7e4e8c92d1e06a5a9d4e77
Source dataset
uspto-grants-2008_01
Patent number
US07323466B2

Reaction notes

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