反应详情

(R)-1-chloro-3-(3-fluoro-4-methoxy)-2-propanol was prepared, using the same procedure as described for example 2, intermediate (d), but from 4-bromo-2-fluoroanisole and (R)-epichlorohydrin. Example 47 was prepared as described for example 1, intermediate (d), but using (R)-1-chloro-3-(3-fluoro-4-methoxy)-2-propanol, to obtain the desired morpholine, example 47 as a pale yellow oil (0.12 g, 19%).

1. custom(R)-1-chloro-3-(3-fluoro-4-methoxy)-2-propanol was prepared
2. customExample 47 was prepared