HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-fluoroanisole → (r)-2-(3-Fluoro-4-methoxybenzyl)morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-fluoroanisole | HCID 75378 | — |
| Reactant | (-)-Epichlorohydrin | HCID 2734062 | — |
| Reactant | N-Boc-(R)-2-(3-bromobenzyl)morpholine | HCID 67073309 | — |
| Product | (r)-2-(3-Fluoro-4-methoxybenzyl)morpholine | HCID 11506852 | — |
Reaction Steps
(R)-1-chloro-3-(3-fluoro-4-methoxy)-2-propanol was prepared, using the same procedure as described for example 2, intermediate (d), but from 4-bromo-2-fluoroanisole and (R)-epichlorohydrin. Example 47 was prepared as described for example 1, intermediate (d), but using (R)-1-chloro-3-(3-fluoro-4-methoxy)-2-propanol, to obtain the desired morpholine, example 47 as a pale yellow oil (0.12 g, 19%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07323466B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-28e6fece09cd48399b4c7c02a57d02dd |
| Source note | uspto-grants-2008_01 |