1-Bromo-2,4-dimethoxybenzene → (R)-1-Chloro-3-(2,4-dimethoxyphenyl)propan-2-ol

HRID 2253003Notes

Reaction equation

HRID 2253003 reaction equation
C(OC(N1CCO[C@H](CC2C=CC=C(Br)C=2)C1)=O)(C)(C)C.[CH3:22][O:23][C:24]1[CH:29]=[C:28]([O:30][CH3:31])[CH:27]=[CH:26][C:25]=1Br.[CH2:33]([C@@H:35]1[O:37][CH2:36]1)[Cl:34]>>[Cl:34][CH2:33][C@H:35]([OH:37])[CH2:36][C:25]1[CH:26]=[CH:27][C:28]([O:30][CH3:31])=[CH:29][C:24]=1[O:23][CH3:22]

Participants

4

Reactant 3

HCID 872661-Bromo-2,4-dimethoxybenzeneHCID 2734062(-)-EpichlorohydrinHCID 67073309N-Boc-(R)-2-(3-bromobenzyl)morpholine

Product 1

HCID 67073072(R)-1-Chloro-3-(2,4-dimethoxyphenyl)propan-2-ol

Procedure

(R)-1-Chloro-3-(2,4-dimethoxyphenyl)-2-propanol was prepared using the same procedure as described for example 2, intermediate (d), but from 2,4-dimethoxybromobenzene and (R)-epichlorohydrin.

Sources & evidence

ORD record
ord-3abfb508adf44bdd92e562877a3aead4
Source dataset
uspto-grants-2008_01
Patent number
US07323466B2

Reaction notes

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