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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2253003Generated: October 28, 2026

1-Bromo-2,4-dimethoxybenzene → (R)-1-Chloro-3-(2,4-dimethoxyphenyl)propan-2-ol

https://huagongshe.com/reaction/2253003

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-2,4-dimethoxybenzeneHCID 87266—
Reactant(-)-EpichlorohydrinHCID 2734062—
ReactantN-Boc-(R)-2-(3-bromobenzyl)morpholineHCID 67073309—
Product(R)-1-Chloro-3-(2,4-dimethoxyphenyl)propan-2-olHCID 67073072—

Reaction Steps

(R)-1-Chloro-3-(2,4-dimethoxyphenyl)-2-propanol was prepared using the same procedure as described for example 2, intermediate (d), but from 2,4-dimethoxybromobenzene and (R)-epichlorohydrin.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07323466B2
Source datasetuspto-grants-2008_01
ORD IDord-3abfb508adf44bdd92e562877a3aead4
Source noteuspto-grants-2008_01