1-Chloroethyl chloroformate → 2-(4-Fluoro-3-methylbenzyl)-morpholine

HRID 2253015Notes

Reaction equation

HRID 2253015 reaction equation
C([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[C:17]([CH3:22])[CH:16]=2)[CH2:9]1)C1C=CC=CC=1.C(N1CCO[C@H](CC2C=CC=C(C=CC3C=NC=CC=3)C=2)C1)(OC(C)(C)C)=O.ClC(OC(Cl)C)=O>>[F:21][C:18]1[CH:19]=[CH:20][C:15]([CH2:14][CH:10]2[O:11][CH2:12][CH2:13][NH:8][CH2:9]2)=[CH:16][C:17]=1[CH3:22]

Participants

4

Reactant 3

HCID 5213051-Chloroethyl chloroformateHCID 67073266N-benzyl-2-(4-fluoro-3-methylbenzyl)-morpholineHCID 67073511N-Boc-(R)-2-(3-(2-(3-pyridinyl)vinyl)-benzyl)morpholine

Product 1

HCID 116441582-(4-Fluoro-3-methylbenzyl)-morpholine

Procedure

Example 71 was prepared as described for example 27, but using N-benzyl-2-(4-fluoro-3-methylbenzyl)-morpholine, intermediate (a) and 1-chloroethyl chloroformate. Example 71 was isolated as a colorless oil (13.7 mg).

Workup

  1. customExample 71 was prepared

Sources & evidence

ORD record
ord-89dcdeaa3dc7442bad80c7b77db87e1a
Source dataset
uspto-grants-2008_01
Patent number
US07323466B2

Reaction notes

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