4-(Bromomethyl)-1-fluoro-2-methylbenzene → N-benzyl-2-(4-fluoro-3-methylbenzyl)-morpholin-3-one

HRID 2253017Notes

Reaction equation

HRID 2253017 reaction equation
C(N1CCO[C@H](CC2C=CC=C(CO)C=2)C1)(OC(C)(C)C)=O.[CH2:23]([N:30]1[CH2:35][CH2:34][O:33][CH2:32][C:31]1=[O:36])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[F:37][C:38]1[CH:45]=[CH:44][C:41]([CH2:42]Br)=[CH:40][C:39]=1[CH3:46]>>[CH2:23]([N:30]1[CH2:35][CH2:34][O:33][CH:32]([CH2:42][C:41]2[CH:44]=[CH:45][C:38]([F:37])=[C:39]([CH3:46])[CH:40]=2)[C:31]1=[O:36])[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

4

Reactant 3

HCID 27781354-(Bromomethyl)-1-fluoro-2-methylbenzeneHCID 122940874-Benzylmorpholin-3-oneHCID 67073062N-Boc-(R)-2-(3-(hydroxymethyl)benzyl)morpholine

Product 1

HCID 67073536N-benzyl-2-(4-fluoro-3-methylbenzyl)-morpholin-3-one

Procedure

N-Benzyl-2-(4-fluoro-3-methylbenzyl)-morpholin-3-one was prepared as described for example 70, intermediate (b), but using 4-benzylmorpholine-3-one and 4-fluoro-3-methylbenzyl bromide and was isolated as a pale yellow oil.

Workup

  1. customwas isolated as a pale yellow oil

Sources & evidence

ORD record
ord-485fe7f3d039470899e552073c84c308
Source dataset
uspto-grants-2008_01
Patent number
US07323466B2

Reaction notes

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