(3-Aminopropoxy)acetic acid → (3-Aminopropoxy)acetic acid

HRID 225302Notes

Reaction equation

HRID 225302 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][O:5][CH2:6][C:7]([OH:9])=O.C[O:11][C:12](=[O:19])[CH2:13][O:14][CH2:15][CH2:16][C:17]#[N:18].[H][H]>C(OC(=O)C)(=O)C.O.[Pt]>[C:7]1(=[O:9])[NH:1][CH2:2][CH2:3][CH2:4][O:5][CH2:6]1.[NH2:18][CH2:17][CH2:16][CH2:15][O:14][CH2:13][C:12]([OH:19])=[O:11]

Participants

8

Reactant 3

HCID 362707(3-Aminopropoxy)acetic acidHCID 23330010HCID 23330010, compoundHCID 178418361HCID 178418361, compound

Product 2

HCID 362707(3-Aminopropoxy)acetic acidHCID 122985791,4-Oxazepan-3-one

Reagents, catalysts & solvents 3

HCID 23939PlatinumCatalystHCID 962WaterSolventHCID 7918Acetic AnhydrideSolvent

Procedure

A process for preparing 6-amino-3-oxahexanoic acid which comprises: contacting methyl-2-cyanoethoxyacetate in excess acetic acid anhydride with hydrogen in the presence of a catalytic amount of platinum to prepare N-acetyl-6-amino-3-oxamethylhexanoate, and heating in excess water at a temperature of about 260° C. to form a mixture comprising 3-oxacaprolactam and 6-amino-3-oxahexanoic acid, extracting said mixture with chloroform, and separating 6-amino-3-oxahexanoic acid from the residue of said extraction.

Sources & evidence

ORD record
ord-f02fc1fe539b48e2800138428702f802
Source dataset
uspto-grants-1980_11
Patent number
US04236028

Reaction notes

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