1-Chloroethyl chloroformate → Morpholine, 2-[[2-(difluoromethoxy)phenyl]methyl]-

HRID 2253022Notes

Reaction equation

HRID 2253022 reaction equation
C([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[O:21][CH:22]([F:24])[F:23])[CH2:9]1)C1C=CC=CC=1.C(N1CCO[C@H](CC2C=CC=C(C=CC3C=NC=CC=3)C=2)C1)(OC(C)(C)C)=O.ClC(OC(Cl)C)=O>>[F:24][CH:22]([F:23])[O:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[CH2:14][CH:10]1[O:11][CH2:12][CH2:13][NH:8][CH2:9]1

Participants

4

Reactant 3

HCID 5213051-Chloroethyl chloroformateHCID 67073057N-benzyl-2-(2-difluoromethoxy-benzyl)-morpholineHCID 67073511N-Boc-(R)-2-(3-(2-(3-pyridinyl)vinyl)-benzyl)morpholine

Product 1

HCID 11601200Morpholine, 2-[[2-(difluoromethoxy)phenyl]methyl]-

Procedure

Example 75 was prepared as described for example 27, but using N-benzyl-2-(2-difluoromethoxy-benzyl)-morpholine, intermediate (a) and 1-chloroethyl chloroformate and example 75 was isolated as a colorless oil (7.9 mg).

Workup

  1. customExample 75 was prepared

Sources & evidence

ORD record
ord-eb80db0ab7d14f9cb5a3f21b3d45bb18
Source dataset
uspto-grants-2008_01
Patent number
US07323466B2

Reaction notes

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