1-(Bromomethyl)-2-(difluoromethoxy)benzene → N-benzyl-2-(2-difluoromethoxy-benzyl)-morpholin-3-one

HRID 2253024Notes

Reaction equation

HRID 2253024 reaction equation
C(N1CCO[C@H](CC2C=CC=C(CO)C=2)C1)(OC(C)(C)C)=O.[CH2:23]([N:30]1[CH2:35][CH2:34][O:33][CH2:32][C:31]1=[O:36])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[F:37][CH:38]([F:48])[O:39][C:40]1[CH:47]=[CH:46][CH:45]=[CH:44][C:41]=1[CH2:42]Br>>[CH2:23]([N:30]1[CH2:35][CH2:34][O:33][CH:32]([CH2:42][C:41]2[CH:44]=[CH:45][CH:46]=[CH:47][C:40]=2[O:39][CH:38]([F:37])[F:48])[C:31]1=[O:36])[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

4

Reactant 3

HCID 27369981-(Bromomethyl)-2-(difluoromethoxy)benzeneHCID 122940874-Benzylmorpholin-3-oneHCID 67073062N-Boc-(R)-2-(3-(hydroxymethyl)benzyl)morpholine

Product 1

HCID 67073097N-benzyl-2-(2-difluoromethoxy-benzyl)-morpholin-3-one

Procedure

N-Benzyl-2-(2-difluoromethoxy-benzyl)-morpholin-3-one was prepared as described for example 70, intermediate (b), but using 4-benzylmorpholine-3-one and 2-difluoromethoxybenzyl bromide and was isolated as a pale yellow oil.

Workup

  1. customwas isolated as a pale yellow oil

Sources & evidence

ORD record
ord-e900543e0aac4b8c840551557739f61b
Source dataset
uspto-grants-2008_01
Patent number
US07323466B2

Reaction notes

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