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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2253024Generated: October 26, 2026

1-(Bromomethyl)-2-(difluoromethoxy)benzene → N-benzyl-2-(2-difluoromethoxy-benzyl)-morpholin-3-one

https://huagongshe.com/reaction/2253024

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-2-(difluoromethoxy)benzeneHCID 2736998—
Reactant4-Benzylmorpholin-3-oneHCID 12294087—
ReactantN-Boc-(R)-2-(3-(hydroxymethyl)benzyl)morpholineHCID 67073062—
ProductN-benzyl-2-(2-difluoromethoxy-benzyl)-morpholin-3-oneHCID 67073097—

Reaction Steps

N-Benzyl-2-(2-difluoromethoxy-benzyl)-morpholin-3-one was prepared as described for example 70, intermediate (b), but using 4-benzylmorpholine-3-one and 2-difluoromethoxybenzyl bromide and was isolated as a pale yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07323466B2
Source datasetuspto-grants-2008_01
ORD IDord-e900543e0aac4b8c840551557739f61b
Source noteuspto-grants-2008_01