O-Cresol → 5-tert-Butyl-m-cresol

HRID 225303Notes

Reaction equation

[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[CH:3][C:2]=1[CH3:8].[CH3:9][C:10]1[C:15](O)=CC=C[CH:11]=1>>[C:10]([C:4]1[CH:5]=[C:6]([OH:7])[CH:1]=[C:2]([CH3:8])[CH:3]=1)([CH3:15])([CH3:11])[CH3:9]

Participants

Reactant 2

HCID 335O-Cresol

HCID 342M-Cresol

Product 1

HCID 786045-tert-Butyl-m-cresolYield 80%

Procedure

Run D of Example 1 is repeated except that 3-cresol is substituted for the cresylic acid mixture. The process results in a selectivity of better than 80 percent of 5-t-butyl-3-cresol.

Sources & evidence

ORD record: ord-29096f09a12a47c1928f4d02f394404a
Source dataset: uspto-grants-1980_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04236031

Reaction notes

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