Bromomethylcyclopropane → HCID 67073288, compound

HRID 2253044Notes

Reaction equation

HRID 2253044 reaction equation
[C:1]([N:8]1[CH2:13][CH2:12][O:11][C@H:10]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH:21]=CC3C=NC=CC=3)[CH:16]=2)[CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].C(OC(N1CCO[C@H](CC2C=[CH:47][CH:46]=[C:45]([CH2:49][OH:50])C=2)C1)=O)(C)(C)C.BrCC1CC1>>[C:4]([O:3][C:1]([N:8]1[CH2:13][CH2:12][O:11][C@H:10]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][O:50][CH2:49][CH:45]3[CH2:46][CH2:47]3)[CH:16]=2)[CH2:9]1)=[O:2])([CH3:5])([CH3:7])[CH3:6]

Participants

4

Reactant 3

HCID 81503BromomethylcyclopropaneHCID 67073062N-Boc-(R)-2-(3-(hydroxymethyl)benzyl)morpholineHCID 67073511N-Boc-(R)-2-(3-(2-(3-pyridinyl)vinyl)-benzyl)morpholine

Product 1

HCID 67073288HCID 67073288, compound

Procedure

The title compound was synthesized in analogy to example 95, intermediate (a), from (R)-2-(3-hydroxymethyl-benzyl)-morpholine-4-carboxylic acid tert-butyl ester and (bromomethyl)cyclopropane to give the compound as colorless oil (56%).

Sources & evidence

ORD record
ord-14b22e81153f414586c192984e7f6e4d
Source dataset
uspto-grants-2008_01
Patent number
US07323466B2

Reaction notes

Loading…