Sodium Carbonate → HCID 12784095, compound

HRID 225328Notes

Reaction equation

HRID 225328 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:21](=[O:22])[N:20]([CH2:23][CH3:24])[C:9]2[N:10]=[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:12]=[CH:13][C:8]=2[C:7]=1Cl)=[O:5])[CH3:2].[CH3:26][N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1.C([O-])([O-])=O.[Na+].[Na+]>C(O)C>[CH2:1]([O:3][C:4]([C:6]1[C:21](=[O:22])[N:20]([CH2:23][CH3:24])[C:9]2[N:10]=[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:12]=[CH:13][C:8]=2[C:7]=1[N:30]1[CH2:31][CH2:32][N:27]([CH3:26])[CH2:28][CH2:29]1)=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 531671-MethylpiperazineHCID 12784117HCID 12784117, compound

Product 1

HCID 12784095HCID 12784095, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 0.9 g. (0.0025 mole) of 5-chloro-7,8-dihydro-8-ethyl-7-oxo-2-phenylpyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (prepared by the method of Example 3, first paragraph) and 0.25 g. (0.0025 mole) of N-methyl piperazine in 40 ml. of ethanol was added 0.27 g. (0.0025 mole) of Na2CO3. The reaction mixture was refluxed for 3 hours after which time it was filtered and chilled in ice. The resulting precipitate was removed by filtration, and rinsed with diethyl ether, giving 0.7 g. of solid--m.p. 180°-185° C.

Workup

  1. temperatureThe reaction mixture was refluxed for 3 hours after which time it
  2. filtrationwas filtered
  3. temperaturechilled in ice
  4. customThe resulting precipitate was removed by filtration
  5. washrinsed with diethyl ether
  6. customgiving 0.7 g

Sources & evidence

ORD record
ord-89419dbd83c9431aa923f6de0e96b729
Source dataset
uspto-grants-1980_11
Patent number
US04236004

Reaction notes

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