Hydrochloric Acid → (2R, 3S)-3-methoxy-2-methylbutyric acid

Temperature

90 °C

This methyl ether (2.55 g) was dissolved in dioxane (50 ml) and conc. hydrochloric acid (36 %, 10 ml) and water (50 ml) were added to the solution. The solution was heated at 90° C. for 5 hours. The reaction mixture was poured into water (100 ml) and the mixture was extracted 4 times with ethyl acetate. The combined extract was dehydrated, concentrated and distilled under reduced pressure (b.p. 105° C./1 mmHg) to obtain (2R, 3S)-3-methoxy-2-methylbutyric acid (1.49 g).

1. extractionthe mixture was extracted 4 times with ethyl acetate
2. extractionThe combined extract
3. concentrationconcentrated
4. distillationdistilled under reduced pressure (b.p. 105° C./1 mmHg)

ORD record

ord-cd6903b1cba84f92b95a3f4335cddf09

Source dataset

uspto-grants-1993_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05232853