Ammonia → HCID 18961157, compound

HRID 2253608Notes

Reaction equation

HRID 2253608 reaction equation
[ClH:1].[CH2:2]([N:9]([CH2:11][CH2:12][CH2:13][NH:14][S:15]([C:18]1[N:19]=[CH:20][N:21]([CH3:23])[CH:22]=1)(=[O:17])=[O:16])C)C1C=CC=CC=1.N>[Pd].C(O)C>[ClH:1].[CH3:2][NH:9][CH2:11][CH2:12][CH2:13][NH:14][S:15]([C:18]1[N:19]=[CH:20][N:21]([CH3:23])[CH:22]=1)(=[O:17])=[O:16]

Participants

5

Reactant 2

HCID 222AmmoniaHCID 18961167HCID 18961167, compound

Product 1

HCID 18961157HCID 18961157, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

15 g (41.7 mmol) of N-[3-(N-benzyl-N-methylamino)-1-propyl]-1-methyl-4-imidazolesulfonamide hydrochloride from Example 28 are hydrogenated in a solution of 100 ml of 25% strength ammonia solution and 100 ml of ethanol in the presence of 2 g of 10% strength Pd/C catalyst. After completion of the absorption of hydrogen and filtering off the catalyst, the filtrate is evaporated in vacuo. The residue is recrystallized from ethanol in order to give the title compound of melting point 169°-170° C.

Workup

  1. customAfter completion of the absorption of hydrogen
  2. filtrationfiltering off the catalyst
  3. customthe filtrate is evaporated in vacuo
  4. customThe residue is recrystallized from ethanol in order

Sources & evidence

ORD record
ord-8f46cd0580af435a890c4a70a5bbfa83
Source dataset
uspto-grants-1993_08
Patent number
US05232922

Reaction notes

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