HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 4-[2-(Ethylamino)ethyl]benzene-1,2-diol;hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 2-(3,4-Dimethoxyphenyl)-N-ethylethan-1-amine | HCID 10750913 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-[2-(Ethylamino)ethyl]benzene-1,2-diol;hydrobromide | HCID 19745961 | — |
Reaction Steps
After dissolving 1.0 g of N-ethyl-homoveratrylamine in a solvent mixture consisting of 6 ml of a 48% aqueous hydrogen bromide solution and 4 ml of acetic acid, the solution was heated at 120°-130° C. with stirring for 5 hours. The solvent was distilled off and the residue was crystallized from ether to obtain 1.2 g of crude crystals. N-Ethyl-3,4-dihydroxyphenethylamine hydrobromide having a melting point of 149°-151° C. was obtained by recrystallizing from isopropyl alcohol. The yield was 0.68 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05232923 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-ee2a10da1d93467ba2d70052e60cf259 |
| Source note | uspto-grants-1993_08 |