Sodium Hydroxide → HCID 23672796, compound

475 mg (2.75 mmole) of methyl N-ethyl-N-n-propyloxamate was dissolved in 10 ml of methanol. The resulting mixture was stirred under ice-cooling. 109 mg (2.75 mmole) of sodium hydroxide was dissolved in 5 ml of water, and the resulting solution was added dropwise to said mixture. After completion of the dropwise addition, the reaction mixture was stirred for 3 hours at room temperature. Methanol was distilled off from the reaction solution under reduced pressure and the remaining aqueous layer was washed with 5 ml of methylene chloride. The aqueous layer was then separated and distilled under reduced pressure, to afford 495 mg (2.7 mmole) of sodium N-ethyl-N-n-propyloxamate as white solids.

1. temperaturecooling
2. additionthe resulting solution was added dropwise
3. additionAfter completion of the dropwise addition
4. stirringthe reaction mixture was stirred for 3 hours at room temperature
5. distillationMethanol was distilled off from the reaction solution under reduced pressure
6. washthe remaining aqueous layer was washed with 5 ml of methylene chloride
7. customThe aqueous layer was then separated
8. distillationdistilled under reduced pressure

ORD record

ord-26e76c03abf84370a743b31e487e881d

Source dataset

uspto-grants-1993_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05232947