Sodium Hydroxide → HCID 23672796, compound

Participants

Reaction Steps

475 mg (2.75 mmole) of methyl N-ethyl-N-n-propyloxamate was dissolved in 10 ml of methanol. The resulting mixture was stirred under ice-cooling. 109 mg (2.75 mmole) of sodium hydroxide was dissolved in 5 ml of water, and the resulting solution was added dropwise to said mixture. After completion of the dropwise addition, the reaction mixture was stirred for 3 hours at room temperature. Methanol was distilled off from the reaction solution under reduced pressure and the remaining aqueous layer was washed with 5 ml of methylene chloride. The aqueous layer was then separated and distilled under reduced pressure, to afford 495 mg (2.7 mmole) of sodium N-ethyl-N-n-propyloxamate as white solids.

Provenance & Evidence