4-Hydroxybenzaldehyde → 4-((2-Methyl-2-propyl)diphenylsilyloxy)benzaldehyde

Participants

Reaction Steps

At 0° C., tert-butyldiphenylchlorosilane (50 g) was added slowly to a solution of p-hydroxybenzaldehyde (22 g) and Et3N (42 mL) in 1,2-dichloroethane (400 mL) and the mixture was stirred at room temperature a few hours. After the usual work up, the product was purified by flash chromatography on silica using EtOAc:hexane 1:10 and was used as such for Step 2.

Provenance & Evidence