HCID 22813129, compound → HCID 22813133, compound

HRID 225377Notes

Reaction equation

HRID 225377 reaction equation
[O:1]=[C:2]([CH2:14][CH2:15][C:16]#[C:17][CH3:18])/[CH:3]=[CH:4]/[C@H:5]1[CH2:12][CH2:11][C@H:10]2[C@@H:6]1[CH2:7][C:8](=[O:13])[O:9]2.[CH3:19][Mg]Br>>[OH:1][C:2]([CH3:19])([CH2:14][CH2:15][C:16]#[C:17][CH3:18])/[CH:3]=[CH:4]/[C@H:5]1[CH2:12][CH2:11][C@H:10]2[C@@H:6]1[CH2:7][C:8](=[O:13])[O:9]2

Participants

3

Reactant 2

HCID 22813129HCID 22813129, compoundHCID 178418573HCID 178418573, compound

Product 1

HCID 22813133HCID 22813133, compound

Procedure

Analogously to Example 7(a), 8 g. of (1S,5R,6R)-6-[(E)-3-oxo-1-octen-6-ynyl]-2-oxabicyclo[3,3,0]octan-3-one [preparation see Example 13(a)] is reacted with methylmagnesium bromide, thus obtaining 6.8 g. of the title compound as a colorless oil.

Workup

  1. customthus obtaining 6.8 g

Sources & evidence

ORD record
ord-f831b957e37a4036834a053b6848e30b
Source dataset
uspto-grants-1980_11
Patent number
US04235930

Reaction notes

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