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HRID2253823

反应详情

EQUATION

反应方程式

HRID 2253823 的结构方程式

REACTANTS

反应物

3
结构：CCO
HCID702

Ethanol

C2H6O

2 次

结构：O=C([O-])O.[Na+]
HCID516892

Sodium Bicarbonate

CHNaO3

结构：CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@@H]5O[C@@H]5C[C@]4(C)[C@H]3CC[C@]12C
HCID54346631

未命名化合物

PRODUCTS

生成物

1
结构：CCO[C@H]1C[C@@]2(C)[C@@H](CC[C@@H]3[C@@H]2CC[C@]2(C)[C@@H](C(C)=O)CC[C@@H]32)C[C@@H]1O
HCID69463654

未命名化合物

收率 40%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O=S(=O)(O)O
催化剂HCID1118

Sulfuric acid

H2O4S

PROCEDURE

实验过程

2α,3α-Epoxy-5α-pregnan-20-one (180 mg) was dissolved in 20 mL of absolute ethanol and cooled to °C. and added to a cold 1.0 mL ethanol solution containing 3-drops of concentrated sulfuric acid. This reaction mixture was stirred for 30 minutes at this temperature and an additional 30 minutes at room temperature, poured into 20% sodium bicarbonate solution and washed several times with chloroform. The combined organic phase was dried over potassium carbonate and concentrated and purified by preparative TLC silica plate in hexane/ethyl acetate (1:1), to give (80 mg, 40% yield) the title compound as fine white crystals.

WORKUP

后处理

  1. temperaturecooled to °C
  2. washwashed several times with chloroform
  3. dry with materialThe combined organic phase was dried over potassium carbonate
  4. concentrationconcentrated
  5. custompurified by preparative TLC silica plate in hexane/ethyl acetate (1:1)