Methanol → HCID 21677047, compound

HRID 2253849Notes

Reaction equation

HRID 2253849 reaction equation
C[Si](C)(C)[N:3]=[S:4]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)([O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:5].CO>>[C:13]1([S:4](=[NH:3])([O:6][C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:5])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 887MethanolHCID 14949202HCID 14949202, compound

Product 1

HCID 21677047HCID 21677047, compoundYield 95%

Procedure

Reactants used in the general procedure were phenyl N-trimethylsilylbenzenesulfonimidate (0.02 mol, 6.10 g) and methanol (0.06 mol, 2.5 ml). Reaction temperature was 22°-25° C.; reaction time was 4 hours. Stripping temperature was less than 35° C.; product yield was 95%. The 1H NMR spectrum of the product (200 MHz, 25% in CDCl3, 1 drop CH3CN) exhibited maxima at the following shift values: 3.78 (s, 1H, broad, NH); 6.88-8.01 (m, 10H, SC6H5, OC6H5).

Workup

  1. customReaction temperature
  2. customwas 22°-25° C.
  3. customreaction time
  4. customwas less than 35° C.

Sources & evidence

ORD record
ord-59b71e1f1ed04c54b7e96877d8d3551a
Source dataset
uspto-grants-1993_08
Patent number
US05233019

Reaction notes

Loading…