Acetic Acid → HCID 19744041, compound

HRID 2254059Notes

Reaction equation

HRID 2254059 reaction equation
C(O)(=O)C.[Cl:5][C:6]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:7]=1[CH2:13][N:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17](=[S:24])[N:16]([CH2:25][C:26]([O:28]CC)=[O:27])[C:15]1=[O:31].Cl.S(=O)(=O)(O)O>O>[Cl:5][C:6]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:7]=1[CH2:13][N:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17](=[S:24])[N:16]([CH2:25][C:26]([OH:28])=[O:27])[C:15]1=[O:31]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 1118Sulfuric AcidHCID 54285914HCID 54285914, compound

Product 1

HCID 19744041HCID 19744041, compoundYield 64.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Into 10 ml of acetic acid were dissolved 500 mg of ethyl 1-(2,4-dichlorophenyl)methyl-1,4-dihydro-2-oxo-4-thioxo-3(2H)-quinazolineacetate, and, after added 3 ml of concentrated hydrochloric acid and then 0.5 ml of concentrated sulfuric acid, the mixture was refluxed for 1 hour. After cooling by allowing to stand, the reaction mixture was poured into 200 ml of water and the deposits were collected by filtration. They were recrystallized from acetic acid to obtain 300 mg of title compound. m.p. 220°-221° C.

Workup

  1. temperatureAfter cooling
  2. filtrationthe deposits were collected by filtration
  3. customThey were recrystallized from acetic acid

Sources & evidence

ORD record
ord-20c3cea3ea21406385504e6a95a4854d
Source dataset
uspto-grants-1993_08
Patent number
US05234928

Reaction notes

Loading…