Sodium Hydroxide → HCID 19744033, compound

HRID 2254062Notes

Reaction equation

HRID 2254062 reaction equation
[OH-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([CH2:11][N:12]2[C:21]3[C:16](=[CH:17][C:18]([CH2:22][C:23]4[NH:24][CH:25]=[CH:26][N:27]=4)=[CH:19][CH:20]=3)[C:15](=[O:28])[N:14]([CH2:29][C:30]([O:32]CC)=[O:31])[C:13]2=[O:35])[CH:7]=[CH:8][C:9]=1[Cl:10]>C(O)C>[Cl:3][C:4]1[CH:5]=[C:6]([CH2:11][N:12]2[C:21]3[C:16](=[CH:17][C:18]([CH2:22][C:23]4[NH:27][CH:26]=[CH:25][N:24]=4)=[CH:19][CH:20]=3)[C:15](=[O:28])[N:14]([CH2:29][C:30]([OH:32])=[O:31])[C:13]2=[O:35])[CH:7]=[CH:8][C:9]=1[Cl:10]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19744037HCID 19744037, compound

Product 1

HCID 19744033HCID 19744033, compoundYield 74.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 1.6 ml of 1N aqueous solution of sodium hydroxide and 20 ml of ethanol were refluxed 0.71 g of ethyl 1-(3,4-dichlorophenyl)methyl-1,4-dihydro-2,4-dioxo-6-imidazolylmethyl-3(2H)-quinazolineacetate for 1 hour. Ethanol was distilled off and the reaction mixture was neutralized with 3N hydrochloric acid. The crystals deposited were collected by filtration, washed with water and dried. They were recrystallized from acetic acid to obtain 0.50 g of title compound. m.p. 243°-244° C.

Workup

  1. distillationEthanol was distilled off
  2. filtrationThe crystals deposited were collected by filtration
  3. washwashed with water
  4. customdried
  5. customThey were recrystallized from acetic acid

Sources & evidence

ORD record
ord-986f370601c54fec897421a9e3d3c467
Source dataset
uspto-grants-1993_08
Patent number
US05234928

Reaction notes

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