Sodium Hydroxide → HCID 19744033, compound

Participants

Reaction Steps

In 1.6 ml of 1N aqueous solution of sodium hydroxide and 20 ml of ethanol were refluxed 0.71 g of ethyl 1-(3,4-dichlorophenyl)methyl-1,4-dihydro-2,4-dioxo-6-imidazolylmethyl-3(2H)-quinazolineacetate for 1 hour. Ethanol was distilled off and the reaction mixture was neutralized with 3N hydrochloric acid. The crystals deposited were collected by filtration, washed with water and dried. They were recrystallized from acetic acid to obtain 0.50 g of title compound. m.p. 243°-244° C.

Provenance & Evidence