HCID 53650643, compound → HCID 19744889, compound

HRID 2254217Notes

Reaction equation

HRID 2254217 reaction equation
[OH:1][C:2]1[C:25]([CH2:26][CH:27]=[C:28]([CH3:30])[CH3:29])=[C:24]([O:31][CH2:32][O:33][CH3:34])[CH:23]=[C:22]([O:35][CH2:36][O:37][CH3:38])[C:3]=1[C:4](=[O:21])[CH:5]=[CH:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[C:10]([O:15][CH2:16][O:17][CH3:18])=[C:9]([O:19][CH3:20])[CH:8]=1>C(OCC)(=O)C.[Pd]>[OH:1][C:2]1[C:25]([CH2:26][CH2:27][CH:28]([CH3:30])[CH3:29])=[C:24]([O:31][CH2:32][O:33][CH3:34])[CH:23]=[C:22]([O:35][CH2:36][O:37][CH3:38])[C:3]=1[C:4](=[O:21])[CH2:5][CH2:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[C:10]([O:15][CH2:16][O:17][CH3:18])=[C:9]([O:19][CH3:20])[CH:8]=1

Participants

4

Reactant 1

HCID 53650643HCID 53650643, compound

Product 1

HCID 19744889HCID 19744889, compoundYield 98.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

Then, 26.9 g of 2'-hydroxy-3,5-dimethoxy-4,4',6'-tris(methoxymethoxy)-3'-(3-methyl-2-butenyl)chalcone was dissolved in 400 ml of ethyl acetate, and catalytic reduction was carried out by using 5% palladium/carbon. The reaction liquid was filtered through Celite to obtain 26.7 g (yield=98.5%) of 1-[2-hydroxy-4,6-bis(methoxymethoxy)-3-isopentylphenyl]-3-(3,5-dimethoxy-4-methoxymethoxyphenyl)-1-propanone.

Workup

  1. customThe reaction liquid
  2. filtrationwas filtered through Celite

Sources & evidence

ORD record
ord-76f2ae9835ee4278be14ad2da36c9b7e
Source dataset
uspto-grants-1993_08
Patent number
US05234951

Reaction notes

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