4-Fluorobenzaldehyde → HCID 54475519, compound

HRID 2254349Notes

Reaction equation

HRID 2254349 reaction equation
[Br-].[C:2]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([OH:4])=[O:3].[F:29][C:30]1[CH:37]=[CH:36][C:33]([CH:34]=O)=[CH:32][CH:31]=1>>[F:29][C:30]1[CH:37]=[CH:36][C:33]([CH:34]=[CH:9][CH2:8][CH2:7][CH2:6][CH2:5][C:2]([OH:4])=[O:3])=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 680234-FluorobenzaldehydeHCID 2779280(5-Carboxypentyl)triphenylphosphanium bromide

Product 1

HCID 54475519HCID 54475519, compoundYield 85.4%

Procedure

5-Carboxypentyl-triphenylphosphonium bromide (20 g) and 4-fluorobenzaldehyde (6.5 g) were subjected to substantially the same reaction as in Reference Example 1. The reaction product was isolated by means of a silica gel chromatography to afford 7-(4-fluorophenyl)-6-heptenoic acid (8.3 g) as white crystals.

Workup

  1. customthe same reaction as in Reference Example 1
  2. customThe reaction product was isolated by means of a silica gel chromatography

Sources & evidence

ORD record
ord-52eb4b38095a495dab6bb646c3b24d25
Source dataset
uspto-grants-1993_08
Patent number
US05235091

Reaction notes

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