HRID2254394

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID115197

Dimethyldioxirane

C3H6O2

结构：CCCCCCCCCCCCCCC1COC2(CC(c3ccccc3)NC(c3ccccc3)C2)O1

HCID86747100

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCC1COC2(CC(c3ccccc3)N(O)C(c3ccccc3)C2)O1

HCID86747101

未命名化合物

收率 65%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

The general procedure of Example 2 is repeated using 10.9 g (22.2 mmol) of 2,6-diphenyl-4-piperidone 1,2-hexadecylene ketal and 376 mL (22.2 mmol) of dimethyldioxirane (0.059M in acetone). 7.3 g (65% yield) of the title compound is isolated as a white solid by recrystallization from ethanol: mp 98°-100° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-76c8d419e1384fdfac140a67c9cba29d
来源数据集: uspto-grants-1993_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05235056
来源说明: uspto-grants-1993_08

反应 SMILES

[CH2:1]1[O:36][C:18]2([CH2:23][CH:22]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[NH:21][CH:20]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH2:19]2)[O:17][CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].CC1(C)O[O:39]1>C(O)C>[CH2:1]1[O:36][C:18]2([CH2:23][CH:22]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[N:21]([OH:39])[CH:20]([C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH2:19]2)[O:17][CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]