Thionyl Chloride → HCID 178478433, compound

HRID 2254431Notes

Reaction equation

HRID 2254431 reaction equation
Cl.O[CH2:3][C:4]1[CH:8]=[C:7](/[CH:9]=[CH:10]/[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:6][N:5]=1.S(Cl)([Cl:19])=O>C(Cl)(Cl)Cl>[Cl:19][CH2:3][C:4]1[CH:8]=[C:7](/[CH:9]=[CH:10]/[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:6][N:5]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 178479672HCID 178479672, compound

Product 1

HCID 178478433HCID 178478433, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
50 °C

Procedure

90 mg of the hydrochloride was dissolved in 3 ml of chloroform, and 0.5 ml of thionyl chloride was added. The mixture was heated at 50° C. for 20 hours. The reaction mixture was evaporated under reduced pressure. The residue was washed with ethyl acetate and filtered to give 60 mg (yield 82%) of the captioned compound as a colorless crystalline powder.

Workup

  1. customThe reaction mixture was evaporated under reduced pressure
  2. washThe residue was washed with ethyl acetate
  3. filtrationfiltered

Sources & evidence

ORD record
ord-1a89d9689d2b43938ea2a250468f5a4b
Source dataset
uspto-grants-1993_08
Patent number
US05234946

Reaction notes

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