Acetone → Ethyl 2-(hydroxymethyl)-1,3-thiazole-4-carboxylate

HRID 2254459Notes

Reaction equation

HRID 2254459 reaction equation
[S:1]1[CH:5]=[C:4]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[N:3]=[C:2]1[C:11](OCC)=[O:12].[BH4-].[Na+].[Cl-].[Ca+2].[Cl-].CC(C)=O>C(O)C>[OH:12][CH2:11][C:2]1[S:1][CH:5]=[C:4]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[N:3]=1

Participants

6

Reactant 4

HCID 180AcetoneHCID 4311764Sodium borohydrideHCID 5284359Calcium ChlorideHCID 197444162,4-Diethyl 2,4-thiazoledicarboxylate

Product 1

HCID 10655181Ethyl 2-(hydroxymethyl)-1,3-thiazole-4-carboxylateYield 64%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

1.5 g of diethyl thiazole-2,4-dicarboxylate was suspended in 15 ml of ethanol, and at -10° C., 0.16 g of sodium borohydride and 3 ml of an ethanol solution of 0.58 g of calcium chloride were added. The mixture was stirred at the above temperature for 2 hours. Acetone was added to decompose the excess of the reducing agent, and the solvent was evaporated under reduced pressure. Dilute sulfuric acid was added to the residue, and insoluble calcium sulfate was separated by filtration. The filtrate was adjusted to pH 10 with an aqueous solution of potassium carbonate, and then extracted with chloroform. The chloroform layer was dried over anhydrous magnesium sulfate and evaporated to dryness under reduced pressure. The residue was treated with isopropyl ether to give 0.78 g (yield 64%) of ethyl 2-hydroxymethylthiazole-4-carboxylate as a colorless crystalline powder.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. additionDilute sulfuric acid was added to the residue, and insoluble calcium sulfate
  3. customwas separated by filtration
  4. extractionextracted with chloroform
  5. dry with materialThe chloroform layer was dried over anhydrous magnesium sulfate
  6. customevaporated to dryness under reduced pressure
  7. additionThe residue was treated with isopropyl ether

Sources & evidence

ORD record
ord-ea213f0378b1424aa7242119f9bcf133
Source dataset
uspto-grants-1993_08
Patent number
US05234946

Reaction notes

Loading…