HCID 54195694, compound → HCID 53911071, compound

HRID 2254472Notes

Reaction equation

HRID 2254472 reaction equation
[S:1]1[CH2:5][CH:4]=[C:3]([C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=2)[CH2:9][OH:10])[CH2:2]1>C(O)C.[C].[Pd]>[S:1]1[CH2:5][CH2:4][CH:3]([C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=2)[CH2:9][OH:10])[CH2:2]1

Participants

4

Reactant 1

HCID 54195694HCID 54195694, compound

Product 1

HCID 53911071HCID 53911071, compoundYield 82.5%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

30 mg of the 3-(2,5-dihydro-3-thienyl)benzyl alcohol obtained in Referential Example 35 was dissolved in 25 ml of ethanol, and in the presence of 50 mg of 10% palladium-carbon, catalytically reduced for 8 hours under a hydrogen pressure of 3.5 kg/cm2. The catalyst was separated by filtration, and the solvent was evaporated under reduced pressure to give 25 mg (yield 82%) of the captioned compound as a colorless oil.

Workup

  1. customThe catalyst was separated by filtration
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-c315cc7e6c7948d09d7765812247f513
Source dataset
uspto-grants-1993_08
Patent number
US05234946

Reaction notes

Loading…