Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 57753122 | HCID 57753122 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 57753058 | HCID 57753058 | — |
Reaction Steps
A mixture of methyl 3-[(4-chloro-2,5-difluorobenzoyl)amino]thiophene-2-carboxylate, MeOH, THF and 1M sodium hydroxide (NaOH) solution (aq) was stirred for two hours at 85° C. to give 3-[(4-chloro-2,5-difluorobenzoyl)amino]thiophene-2-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07557112B2 |
|---|
| Source dataset | uspto-grants-2009_07 |
|---|
| ORD ID | ord-829abd3451104697af8dd803b114a292 |
|---|
| Source note | uspto-grants-2009_07 |
|---|
