Methanol → HCID 57753058, compound

HRID 225453Notes

Reaction equation

HRID 225453 reaction equation
[Cl:1][C:2]1[C:19]([F:20])=[CH:18][C:5]([C:6]([NH:8][C:9]2[CH:13]=[CH:12][S:11][C:10]=2[C:14]([O:16]C)=[O:15])=[O:7])=[C:4]([F:21])[CH:3]=1.CO.[OH-].[Na+]>C1COCC1>[Cl:1][C:2]1[C:19]([F:20])=[CH:18][C:5]([C:6]([NH:8][C:9]2[CH:13]=[CH:12][S:11][C:10]=2[C:14]([OH:16])=[O:15])=[O:7])=[C:4]([F:21])[CH:3]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 57753122HCID 57753122, compound

Product 1

HCID 57753058HCID 57753058, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
85 °C

Procedure

A mixture of methyl 3-[(4-chloro-2,5-difluorobenzoyl)amino]thiophene-2-carboxylate, MeOH, THF and 1M sodium hydroxide (NaOH) solution (aq) was stirred for two hours at 85° C. to give 3-[(4-chloro-2,5-difluorobenzoyl)amino]thiophene-2-carboxylic acid.

Sources & evidence

ORD record
ord-829abd3451104697af8dd803b114a292
Source dataset
uspto-grants-2009_07
Patent number
US07557112B2

Reaction notes

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