HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 225454Generated: November 1, 2026
Hydrochloric Acid → 2-Thiophenecarboxylic acid, 3-[(2,5-difluoro-4-methoxybenzoyl)amino]-4-methyl-
https://huagongshe.com/reaction/225454
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 57753051 | HCID 57753051 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Thiophenecarboxylic acid, 3-[(2,5-difluoro-4-methoxybenzoyl)amino]-4-methyl- | HCID 69092888 | — |
Reaction Steps
After a mixture of methyl 4-methyl-3-[(2,4,5-trifluorobenzoyl)amino]thiophene-2-carboxylate, MeOH, THF and 1M NaOH aq was stirred at 70° C., 1M of hydrochloric acid aq was added and the extracted solid was filtered to give 3-[(2,5-difluoro-4-methoxybenzoyl)amino]-4-methythiophene-2-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07557112B2 |
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| Source dataset | uspto-grants-2009_07 |
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| ORD ID | ord-1208635cfa664b3f8817570b644ec1af |
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| Source note | uspto-grants-2009_07 |
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