Hydrochloric Acid → 2-Thiophenecarboxylic acid, 3-[(2,5-difluoro-4-methoxybenzoyl)amino]-4-methyl-

HRID 225454Notes

Reaction equation

HRID 225454 reaction equation
[CH3:1][C:2]1[C:3]([NH:11][C:12](=[O:22])[C:13]2[CH:18]=[C:17]([F:19])[C:16](F)=[CH:15][C:14]=2[F:21])=[C:4]([C:7]([O:9]C)=[O:8])[S:5][CH:6]=1.[CH3:23][OH:24].[OH-].[Na+].Cl>C1COCC1>[F:21][C:14]1[CH:15]=[C:16]([O:24][CH3:23])[C:17]([F:19])=[CH:18][C:13]=1[C:12]([NH:11][C:3]1[C:2]([CH3:1])=[CH:6][S:5][C:4]=1[C:7]([OH:9])=[O:8])=[O:22]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 57753051HCID 57753051, compound

Product 1

HCID 690928882-Thiophenecarboxylic acid, 3-[(2,5-difluoro-4-methoxybenzoyl)amino]-4-methyl-

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
70 °C

Procedure

After a mixture of methyl 4-methyl-3-[(2,4,5-trifluorobenzoyl)amino]thiophene-2-carboxylate, MeOH, THF and 1M NaOH aq was stirred at 70° C., 1M of hydrochloric acid aq was added and the extracted solid was filtered to give 3-[(2,5-difluoro-4-methoxybenzoyl)amino]-4-methythiophene-2-carboxylic acid.

Workup

  1. filtrationthe extracted solid was filtered

Sources & evidence

ORD record
ord-1208635cfa664b3f8817570b644ec1af
Source dataset
uspto-grants-2009_07
Patent number
US07557112B2

Reaction notes

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