Azane;hydrate → HCID 136010432, compound

HRID 225456Notes

Reaction equation

HRID 225456 reaction equation
O.[NH3:2].[Cl:3][C:4]1[C:22]([F:23])=[CH:21][C:7]([C:8]([NH:10][C:11]2[N:20]=[CH:19][CH:18]=[CH:17][C:12]=2[C:13](OC)=[O:14])=O)=[C:6]([F:24])[CH:5]=1>C(Cl)(Cl)Cl.CO>[Cl:3][C:4]1[C:22]([F:23])=[CH:21][C:7]([C:8]2[NH:2][C:13](=[O:14])[C:12]3[CH:17]=[CH:18][CH:19]=[N:20][C:11]=3[N:10]=2)=[C:6]([F:24])[CH:5]=1

Participants

4

Reactant 2

HCID 12896473Azane;hydrateHCID 57753062HCID 57753062, compound

Product 1

HCID 136010432HCID 136010432, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

28% ammonia water was added to a chloroform-MeOH solution of methyl 2-[(4-chloro-2,5-difluorobenzoyl)amino]nicotinate and the resultant was stirred all night at room temperature to give 2-(4-chloro-2,5-difluorophenyl)pyrido[2,3-d]pyrimidine-4(3H)-one.

Sources & evidence

ORD record
ord-6d48da911c6440469ce466e08df9128f
Source dataset
uspto-grants-2009_07
Patent number
US07557112B2

Reaction notes

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