HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromomethyl-3,4-dihydro-4-oxo-3-((pivaloyl)oxy)methylquinazoline → Diethyl N-(2-fluoro-4-(N-((3,4-dihydro-4-oxo-3((pivaloyl)oxy)methyl-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-L-glutamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromomethyl-3,4-dihydro-4-oxo-3-((pivaloyl)oxy)methylquinazoline | HCID 13691213 | — |
| Reactant | Diethyl N-(4-(N-((3,4-dihydro-4-oxo-3-((pivaloyl)oxy) methyl-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-L-glutamate | HCID 13691215 | — |
| Reactant | Diethyl N-(2-fluoro-4-(N-prop-2-ynylamino)benzoyl)-L-glutamate | HCID 14730572 | — |
| Product | Diethyl N-(2-fluoro-4-(N-((3,4-dihydro-4-oxo-3((pivaloyl)oxy)methyl-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-L-glutamate | HCID 14730576 | — |
Reaction Steps
The compound was prepared from compound (9) in a similar manner to that for the preparation of compound (5) from compound (4) in Example 1 using the reagent quantities and conditions set out in Table A.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05236927 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-873d4085b5224f0793c6920dff159445 |
| Source note | uspto-grants-1993_08 |