HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl N-(4-(N-((3,4-dihydro-4-oxo-3-((pivaloyl)oxy) methyl-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-L-glutamate → (S)-2-(2-fluoro-4-(((4-oxo-3,4-dihydroquinazolin-6-yl)methyl)(prop-2-ynyl)amino)benzamido)pentanedioic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl N-(4-(N-((3,4-dihydro-4-oxo-3-((pivaloyl)oxy) methyl-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-L-glutamate | HCID 13691215 | — |
| Reactant | Diethyl N-(2-fluoro-4-(N-((3,4-dihydro-4-oxo-3((pivaloyl)oxy)methyl-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-L-glutamate | HCID 14730576 | — |
| Product | (S)-2-(2-fluoro-4-(((4-oxo-3,4-dihydroquinazolin-6-yl)methyl)(prop-2-ynyl)amino)benzamido)pentanedioic acid | HCID 136035435 | — |
Reaction Steps
This compound was prepared from compound (10) in a similar manner to that for the preparation of CB 3804 from compound 5 in Example 1 using the reagent quantities and conditions set out in Table B.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05236927 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-8e6055fa44d6425ea2652da54e6f9419 |
| Source note | uspto-grants-1993_08 |