Tetrahydro-4H-pyran-4-one → HCID 14985860, compound

HRID 2254585Notes

Reaction equation

HRID 2254585 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11](Br)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:16]1[CH2:21][CH2:20][C:19](=[O:22])[CH2:18][CH2:17]1>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:19]2([OH:22])[CH2:20][CH2:21][O:16][CH2:17][CH2:18]2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 121599Tetrahydro-4H-pyran-4-oneHCID 27566381-(Benzyloxy)-3-bromobenzene

Product 1

HCID 14985860HCID 14985860, compoundYield 77%

Procedure

Using the Grignard reaction procedure described in the portion of Example 1 which is concerned with the preparation of starting materials, 3-benzyloxybromobenzene was reacted with tetrahydropyran-4-one to give 4-(3-benzyloxyphenyl)-4-hydroxytetrahydropyran in 77% yield, m.p. 84°-86° C.

Workup

  1. customthe Grignard reaction procedure

Sources & evidence

ORD record
ord-c4363910e2434c2ba538fd2c15eb6543
Source dataset
uspto-grants-1993_08
Patent number
US05236919

Reaction notes

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