Sodium Hydroxide → HCID 178517531, compound

HRID 225460Notes

Reaction equation

HRID 225460 reaction equation
[Br:1][C:2]1[C:18]([F:19])=[CH:17][C:5]([C:6]([NH:8][C:9]2[CH:13]=[CH:12][S:11][C:10]=2[C:14]([NH2:16])=[O:15])=O)=[C:4]([F:20])[CH:3]=1.[OH-].[Na+]>CO>[Br:1][C:2]1[C:18]([F:19])=[CH:17][C:5]([C:6]2[NH:8][C:9]3[CH:13]=[CH:12][S:11][C:10]=3[C:14](=[O:15])[N:16]=2)=[C:4]([F:20])[CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 577530493-[(4-Bromo-2,5-difluorobenzoyl)amino]thiophene-2-carboxamide

Product 1

HCID 178517531HCID 178517531, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 3-[(4-bromo-2,5-difluorobenzoyl)amino]thiophene-2-carboxamide; 1M NaOH aq and MeOH was stirred for two hours at 80° C. to give 2-(4-bromo-2,5-difluorophenyl)thieno[3,2-d]pyrimidine-4(1H)-one.

Sources & evidence

ORD record
ord-fa1daa4fe4a74a1ca37039c3c8f1a8fc
Source dataset
uspto-grants-2009_07
Patent number
US07557112B2

Reaction notes

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