反应详情

A solution of 54 mg of 5-(p-cyanophenyl)imidazo[1,5-a]pyridine hydrochloride in 5.0 ml methanol is hydrogenated at room temperature and atmospheric pressure for 30 min with 0.1 g of 10% palladium on charcoal. The catalyst is filtered and 0.21 ml of 1N sodium hydroxide is added. The filtrate is evaporated, taken up in 10 ml of methylene chloride and filtered through Celite®. Evaporation yields an oil which is chromatographed on silica gel with ethyl acetate to yield the title compound, m.p. 117°-118°.

1. customis hydrogenated at room temperature
2. filtrationThe catalyst is filtered
3. addition0.21 ml of 1N sodium hydroxide is added
4. customThe filtrate is evaporated
5. filtrationfiltered through Celite®
6. customEvaporation
7. customyields an oil which
8. customis chromatographed on silica gel with ethyl acetate