1-Chloroethyl chloroformate → HCID 86615853, compound

HRID 225476Notes

Reaction equation

HRID 225476 reaction equation
C([N:8]1[CH2:13][CH2:12]/[C:11](=[CH:14]\[C:15]([O:17][CH2:18][CH3:19])=[O:16])/[CH:10]([CH3:20])[CH2:9]1)C1C=CC=CC=1.ClC(OC(Cl)C)=O>>[CH3:20][CH:10]1[CH2:9][NH:8][CH2:13][CH2:12]/[C:11]/1=[CH:14]\[C:15]([O:17][CH2:18][CH3:19])=[O:16]

Participants

3

Reactant 2

HCID 5213051-Chloroethyl chloroformateHCID 10730982HCID 10730982, compound

Product 1

HCID 86615853HCID 86615853, compound

Procedure

A mixture of ethyl (2E)-(1-benzyl-3-methylpiperidine-4-ylidene)acetate, 1-chloroethyl chloroformate and 1,2-dicholoroethane was stirred for 30 minutes heated to reflux and concentrated under reduced pressure. The residue was dissolved in EtOH and stirred for 10 minutes heated to reflux to give ethyl (2E)-(3-methylpiperidine-4-ylidene)acetate.

Workup

  1. temperatureheated
  2. temperatureto reflux
  3. concentrationconcentrated under reduced pressure
  4. dissolutionThe residue was dissolved in EtOH
  5. stirringstirred for 10 minutes
  6. temperatureheated
  7. temperatureto reflux

Sources & evidence

ORD record
ord-15c348654bd0412f8dbf9bc983dfcf83
Source dataset
uspto-grants-2009_07
Patent number
US07557112B2

Reaction notes

Loading…