Hydrogen Bromide → 1-Octanol, 8-bromo-

In a 6 m3 kettle, 235 kg of octane-1,8-diol were stirred under reflux with 3 m3 of toluene and 440 kg of HBr (48% strength) for 40 hours. The aqueous phase was then separated off. The toluene phase was thoroughly washed with 500 1 of water, then with 500 l of 10% strength sodium carbonate solution and then again with 500 1 of water. A sample was concentrated and was found to contain 92% of bromooctanol in addition to 1.9% of dibromooctane and 2.0% unconverted octanediol. After removal of the toluene by distillation in the reaction kettle and a Sambay distillation of the remaining residue, the yield was 254 kg (76%).

1. customThe aqueous phase was then separated off
2. washThe toluene phase was thoroughly washed with 500 1 of water
3. concentrationA sample was concentrated
4. additionin addition to 1.9% of dibromooctane and 2.0% unconverted octanediol
5. customAfter removal of the toluene
6. distillationby distillation in the reaction kettle
7. distillationa Sambay distillation of the remaining residue

ORD record

ord-2dd3f3ab35d94dc6914d18ac935d2b39

Source dataset

uspto-grants-1993_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05237113