HCID 178418546, compound → HCID 178461195, compound

HRID 2254936Notes

Reaction equation

HRID 2254936 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[O:13][CH2:12][CH:11]([C@H:14]3[CH2:19][CH2:18][C@H:17]([CH2:20]CC)[CH2:16][CH2:15]3)[CH2:10][O:9]2)=[CH:4][C:3]=1[F:23].[C:24]([Cu])#[N:25]>CN1C(=O)CCC1>[C:24]([C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[O:13][CH2:12][C@H:11]([C@H:14]3[CH2:19][CH2:18][C@H:17]([CH3:20])[CH2:16][CH2:15]3)[CH2:10][O:9]2)=[CH:4][C:3]=1[F:23])#[N:25]

Participants

4

Reactant 2

HCID 178418546HCID 178418546, compoundHCID 178447929HCID 178447929, compound

Product 1

HCID 178461195HCID 178461195, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

In 40 cm3 of NMP, 6.2 g (0.016 mol) of 2-(4'-bromo-3'-fluorophenyl)-5-(trans-4'-propylcyclohexyl)-1,3-dioxane and 2.2 g (0.024 mol) of CuCN were refluxed with a mantle heater for 2 hours.

Sources & evidence

ORD record
ord-fcee343a2e554d1e8f23a0e2aa458b68
Source dataset
uspto-grants-1993_08
Patent number
US05238599

Reaction notes

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