1-Methylpiperazin-2-one → 4-[(4-Methyl-3-oxo-1-piperazinyl)methyl]benzoic acid

HRID 225504Notes

Reaction equation

HRID 225504 reaction equation
[O:1]=[C:2]1[NH:7][CH2:6][CH2:5][N:4]([CH2:8][C:9]2[CH:17]=[CH:16][C:12]([C:13]([OH:15])=[O:14])=[CH:11][CH:10]=2)[CH2:3]1.[CH3:18]N1CCNCC1=O>>[CH3:18][N:7]1[CH2:6][CH2:5][N:4]([CH2:8][C:9]2[CH:17]=[CH:16][C:12]([C:13]([OH:15])=[O:14])=[CH:11][CH:10]=2)[CH2:3][C:2]1=[O:1]

Participants

3

Reactant 2

HCID 43990421-Methylpiperazin-2-oneHCID 167770994-((3-Oxopiperazin-1-yl)methyl)benzoic acid

Product 1

HCID 117367634-[(4-Methyl-3-oxo-1-piperazinyl)methyl]benzoic acid

Procedure

Utilising the procedure described for 4-[(3-oxo-1-piperazinyl)methyl]benzoic acid, but employing 1-methylpiperazin-2-one in place of piperazin-2-one afforded the title compound as cream crystalline solid.

Sources & evidence

ORD record
ord-1c098bc3ff1c41d6b07ed297c5daf73c
Source dataset
uspto-grants-2009_07
Patent number
US07557105B2

Reaction notes

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