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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 225504Generated: October 30, 2026

1-Methylpiperazin-2-one → 4-[(4-Methyl-3-oxo-1-piperazinyl)methyl]benzoic acid

https://huagongshe.com/reaction/225504

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Methylpiperazin-2-oneHCID 4399042—
Reactant4-((3-Oxopiperazin-1-yl)methyl)benzoic acidHCID 16777099—
Product4-[(4-Methyl-3-oxo-1-piperazinyl)methyl]benzoic acidHCID 11736763—

Reaction Steps

Utilising the procedure described for 4-[(3-oxo-1-piperazinyl)methyl]benzoic acid, but employing 1-methylpiperazin-2-one in place of piperazin-2-one afforded the title compound as cream crystalline solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07557105B2
Source datasetuspto-grants-2009_07
ORD IDord-1c098bc3ff1c41d6b07ed297c5daf73c
Source noteuspto-grants-2009_07